Tweet Spinner (disclosure: affiliate link) is a great Twitter management tool. You can use it for managing friends and followers, following tweets with certain keywords, preventing spam and automating tweets.
In the initial stages of using Twitter you can use this tool to follow people and tweets with keywords of your choice. As the number of your followers increases Tweet Spinner would also be useful for identifying and removing unwanted followers and preventing spam.
You can read some reviews here and signup for a free trial at tweetspinner.com.
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